HOOK1 and oropharynx squamous cell carcinoma: Although its molecular function is not clear, some studies have indicated that it interacts with HOOK1 in haploid male germ cells [22], and it is a methylation-driven gene associated with the progression and prognosis of lung adenocarcinoma [23, 24], human papillomavirus-related oropharyngeal squamous cell carcinoma [25], prostate cancer [26–29], and breast cancer [30].