AD is a neurodegenerative disease, and its pathogenesis includes brain atrophy, amyloid-β (Aβ) plaque deposit [11], tau protein aggregates in the form of intracellular neurofibrillary tangles (NFTs), and other pathological changes that cause the formation of senile plaque (SP) [12, 13]. The gene discussed is MAPT; the disease is Alzheimer disease.