After adjusting for other confounders including AF type and BMI, PACS1-day (HR 1.11, 95% CI 1.05–1.18, p = 0.0003), PACS1-day ≥ -12% (HR 2.53, 95% CI 1.54–4.16, p = 0.0003) and PACS1-day quartiles (HR 4.23, 95% CI 2.08–8.75, P < 0.0001) were the only independent predictor of arrhythmia recurrence after AF ablation in Model 1, 2 and 3, respectively. This evidence concerns the gene PACS1 and cardiac arrhythmia.