Interestingly, the cancer genome atlas (TCGA) HNSCC RNA expression dataset revealed a positive correlation between LCK and LAPTM5, KIF21B and LPXN, as well as negative expression correlation of LCK with TGM1, KRT14 and KRT17 further supporting the idea that these genes are regulated by LCK signaling in oral cancer cells (Supplementary Fig. 5A). Here, LAPTM5 is linked to lip and oral cavity carcinoma.