Module 2 contained 6 DEGs (ANAPC4, HIST2H2BD, HIST2H2BE, etc.), and these genes were mainly enriched in 7 GO terms and 4 KEGG pathways, such as nucleosome assembly (GO: 0006334), protein-DNA complex assembly (GO: 0065004), and pathways like systemic lupus erythematosus pathology (hsa05016). This evidence concerns the gene H2BC21 and systemic lupus erythematosus.