TOP2A and juvenile Huntington disease: Module 1 contained 18 up-regulated genes, including TOP2A, KIF11, CCDC114 and DNAI2, etc. The genes in Module 1 were significantly enriched in 14 GO terms and only one KEGG pathway, such as microtubule-based movement (GO: 0007018), mitotic cytokinesis (GO: 0000281) and Huntington’s disease (hsa04610).