Despite the unquestioned success of cART in recovering CD4 T-cell count and in preventing disease progression [1–3], a few-year survival gap has been described in large cohorts of successfully cART-treated people living with HIV (PLWHIV) when compared to HIV-negative individuals [4–6], mainly ascribable to an excess risk of serious non-AIDS events (SNAEs) (as reviewed in [7]). Here, CD4 is linked to AIDS.