Lin et al. demonstrated in a population of 152 patients a significant correlation between the serum EGF levels and lymph node metastasis (p = 0.026), worse survival (p = 0.002) and advanced TNM stage (p = 0.040) in oral squamous cell carcinoma patients (OSCC). This evidence concerns the gene EGF and metastatic malignant neoplasm in the lymph nodes.