Mosaad Zaki et al. confirmed that the expression level of ENTPD1 on CD4+ T helper cells in chronic lymphocytic leukemia (CLL) patients was significantly higher than that in the controls, and ENTPD1 and CD4 expression levels were remarkably expressed in high-risk CLL patients [31]. Here, ENTPD1 is linked to B-cell chronic lymphocytic leukemia.