The commonly prescribed drugs for hypertension (Propranolol, Metoprolol, Telmisartan, Losartan) and T2DM (Glimepiride, and Pioglitazone) shares the same drug metabolizing enzymes (CYP1A2, CYP3A4, CYP2C9, and CYP2D6). Here, CYP1A2 is linked to type 2 diabetes mellitus.