APC and malignant colon neoplasm: Table 2 include a number of pairs for colon cancer that can be directly mapped to specific signaling pathways. The APC ⇒ AXIN2 pair participates into Wnt signaling, while the MAML1 ⇒ PBX1 pair is part of the Notch3 signaling network. Both these pathways are known to regulate the homeostasis of the colonic epithelium, and their alterations are well documented in colon cancer [49].