For example, in the STPs shown for colon cancer in Table 1, APC is the source gene, AXIN2 is the target gene, and there exists a directed signaling path from APC to AXIN2 of length at most three links (two intermediate genes) in Reactome such that the second-to-last link, namely the direct parent of AXIN2, controls the mRNA expression of AXIN2. Here, AXIN2 is linked to colonic neoplasm.