To this end, we analyzed the list of genes up regulated by TMZ in G7 GBM stem cells using data found in our previous publication [31] and oPPOSUM [53–55], and identified several TF consensus sites enriched in the promoters of these genes, including YY1 and ZEB1 (Figure 4A and Supplementary Table 1), both of which were found to be physically associated with the 824-promoter region (Figure 3B). Here, ZEB1 is linked to glioblastoma.