MNA is a strong biomarker associated with rapid tumor growth.9 Other copy-number alterations occur over more extensive chromosome regions, with segmental chromosome alterations being associated with a poor outcome.10 Recurrent mutations have been described in the RAS-MAPK pathway, chromatin remodeling genes (ATRX and ARID1A), and TERT rearrangements.11-14. This evidence concerns the gene TERT and neoplasm.