In addition, we found that co-incubation with an antibody against integrin αV markedly reduced CXCL2-provoked adhesion of colon cancer cells to vitronectin, fibronectin and fibrinogen but not to collagen IV and laminin I, indicating that CXCL2-induced adhesion of colon cancer cells to certain ECM proteins is dependent on αV integrins. This evidence concerns the gene VTN and malignant colon neoplasm.