Considered together, targeting the CXCL2-CXCR2 axis might inhibit colon cancer spread in the peritoneal cavity via several different mechanisms, i.e. on one hand decreasing cancer cell adhesion, migration and proliferation and on the other hand attenuating neutrophil recruitment and deposition of extracellular traps. This evidence concerns the gene CXCL2 and colonic neoplasm.