These findings were validated in a human colon cancer cell line (HT-29) showing that the human homologue of the murine CXCR2 ligand CXCL2 provoked proliferation and migration in a CXCR1/2-dependent manner in HT-29 cells, suggesting that our findings could be extrapolated to humans. Here, CXCR1 is linked to malignant colon neoplasm.