LGI1 and encephalitis: Since the detection of autoantibodies against neuronal surface antigens, AE, a kind of encephalitis caused by specific neuronal antigens, has been more frequently diagnosed, especially in patients with symptoms of LE.[4,5] Voltage-gated potassium channel (VGKC)-related antibodies are not directed at the VGKC itself but at 2 closely associated proteins, leucine-rich glioma-inactivated 1 (LGI1) and CASPR2.[6]