CNTNAP2 and meningioma: Contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive limbic encephalitis (LE) is a rare clinical disease capable of causing neuromuscular rigidity, Morvan syndrome, and LE and manifests as seizures, amnesia, cognitive disturbances, neuromyotonia, movement disorders, pain, and sleep disturbances.[2] Peritumoral brain edema (PTBE) associated with meningiomas can lead to histological blood-brain barrier (BBB) breakdown.