Furthermore, other immunological alterations are observed in COVID-19 patients, such as regulatory cells dysfunction and increased circulating TH17 cytokines like IL-17 among all.[31,35,36] Lack of regulatory function likely associated with an increase in circulating IL-17, whose axis is implicated in PsA pathogenesis,[37,38] add complexity to the riddle of COVID-19 role in inflammatory arthritis development. This evidence concerns the gene IL17A and COVID-19.