LEP and central nervous system cancer: The RT- qPCR assay showed that the four AGs (LEP, TERT, PON1, and SSTR3) were expressed to different extents in normal brain tissue (NBT), lower-grade glioma (LGG) and Glioblastoma (GBM) tissue in mRNA expression level (Figure 8A–8D), and the immunohistochemistry assay revealed that the protein expression of four AGs were also expressed to different extents in NBT and glioma tissue (Figure 8E–8H), in accord with the bioinformatics results.