But the results for PON1 and SSTR3, as protective factors, were not in accord with the risk score results; glioma patients of the high-LEP-expression subtype included a higher fraction of naïve B cells, plasma cells, NK activated cells, and monocytes than did those of low-LEP-expression subtype, while CD4 memory resting T cells and M0 macrophages showed the opposite result (P < 0.05, Figure 7D). Here, LEP is linked to central nervous system cancer.