Several immunosuppressive treatment approaches are being studied or used in clinical practice to ameliorate hyperinflammation-associated morbidity in patients who have already developed severe complications of COVID-19, including blocking specific cytokine signaling axes (e.g., IL-6, IL-1, or TNF-alpha) and broader immunosuppressive approaches (e.g. dexamethasone or baricitinib) (Investigators et al., 2021; RECOVERY Collaborative Group, 2021; Huet et al., 2020; Rosas et al., 2021; Salama et al., 2021; Stone et al., 2020). This evidence concerns the gene IL6 and COVID-19.