IL20RA and IL20RB are also detected in tumors of epithelial origin including breast cancer, non-small-cell lung cancer, and bladder cancer, while IL-20 subfamily of cytokines has been reported to have either tumor-promoting or tumor-suppressing roles depending on tumor types and the local immune environment (Gopalan et al., 2007; Lee et al., 2013; Pestka et al., 2004; Rutz et al., 2014; Whitaker et al., 2012). This evidence concerns the gene IL20 and neoplasm.