LRRK2 and Parkinson disease: Mitochondrial impairment has been observed in post-mortem human tissues from PD patients with LRRK2 mutations, various animal models of G2019S LRRK2-mediated PD (Cooper et al., 2012; Hsieh et al., 2016; Mortiboys et al., 2010; Sanders et al., 2014; Yue et al., 2015) and cellular models of the disease (Cherra et al., 2013; Niu et al., 2012; Singh et al., 2019; Su and Qi, 2013; Wang et al., 2012).