Lewy pathology is neuron-specific in LBD, suggesting a crucial role of intraneural α-synuclein in LBD pathology that is distinct from the cytoplasmic α-synuclein inclusions of glial cells in multiple system atrophy (Jucker and Walker 2013; Del Tredici and Braak 2020). This evidence concerns the gene SNCA and multiple system atrophy.