We focused on experimentally validated human PPIs of HSP genes, not including genes associated with a disease spectrum in which HSP is involved (e.g., HSP-ataxia spectrum) or genes with related phenotype, in contrast with prior studies (Parodi et al., 2018; Novarino et al., 2014; Synofzik and Schule, 2017; Bis-Brewer et al., 2019). This evidence concerns the gene HSP90B2P and cerebellar ataxia.