One group reported that hepatic SAA1-induced chemokine production may exacerbate T-cell-mediated hepatitis (Ji et al., 2015), while other reports indicate that SAA1 may exhibit cytokine-like property, and it can be easily recognized by cell-to-cell communication and feedback response in inflammatory, immunogenic, and protective pathways (Baranova et al., 2005; He et al., 2003; Jijon et al., 2005). The gene discussed is SAA1; the disease is Hepatitis.