A potential oncogenic role of PRC1.1 is underlined by the fact that KDM2B is overexpressed in leukemias, breast cancer, and pancreatic cancer and conversely knockdown of KDM2B abrogated tumorigenicity (Andricovich et al., 2016; He et al., 2011; Kottakis et al., 2014; Ueda et al., 2015; van den Boom et al., 2016). The gene discussed is KDM2B; the disease is breast carcinoma.