Of course it is evident that USP7 can function in several pathways, often through regulating protein stability of tumor suppressors or epigenetic regulators (Carra et al., 2017; Felle et al., 2011; van der Horst et al., 2006) and it is particularly the TP53 pathway that is strongly controlled by USP7 (Colland et al., 2009; Fan et al., 2013; Hu et al., 2006; Ye et al., 2015). This evidence concerns the gene USP7 and neoplasm.