AKAP4 is highly expressed in a variety of cancers, and the regulatory subunit PKAI of PKA has also been shown to play important roles in promoting the proliferation and transformation of tumors and the generation of immunosuppressive microenvironments in the tumor microenvironment (TME) (Brown et al., 2003; Hussain et al., 2015; Martinez et al., 2018). Here, AKAP4 is linked to cancer.