In contrast, urinary ACE2 or TMPRSS2 levels did not correlate with urinary SARS-CoV-2 N measurements or AKI at any time point (Table 2), implicating that urinary clearance of SARS-CoV-2 N more reflects systemic inflammation due to viral spread rather than renal cell death by direct viral infection of the kidneys. The gene discussed is TMPRSS2; the disease is acute kidney injury.