Based on the assumption that AKI in COVID-19 is caused by direct viral infection of the kidneys, it was unclear whether markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins essential for viral entry (ACE2, TMPRSS2) are detectable in urinary samples of patients with AKI in COVID-19. This evidence concerns the gene TMPRSS2 and acute kidney injury.