Overexpression of CAGE increased autophagic flux (Supplementary Figure 3A), invasion potential (Supplementary Figure 3B), proliferation potential (Supplementary Figure 3C), tumor spheroid-forming potential, and the expression of SRY-Box Transcription Factor 2 (SOX2), an indicator of cancer stemness (Supplementary Figure 3D); however, it decreased the apoptotic effects of anticancer drugs in AGSR△CAGE#5 and AGSR△CAGE#7 cell lines (Supplementary Figure 3E). Here, SOX2 is linked to cancer.