The C-terminal transmembrane fragment mediates SDC1-dependent functions in cell proliferation, migration, invasion, and metastasis formation (Pasqualon et al., 2015b), whereas the cytoplasmic C-terminal fragment of SDC1 generated by γ-secretase inhibits SDC1-dependent tumor cell migration and invasion by increasing the phosphorylation of Src and focal adhesion kinase (Pasqualon et al., 2015a). This evidence concerns the gene SDC1 and neoplasm.