A recent study demonstrated abnormal Akt signaling in infertile women with non-cavity-distorting intramural UFs; these women exhibited higher expressions of Akt1, Akt2, p-Akt, and phospho-PTEN and a lower expression of PTEN mRNA in the endometrium compared to fertile women (Makker et al., 2018). This evidence concerns the gene AKT2 and Infertility.