MAPT and Alzheimer disease: Recent cellular and mouse model study shows some promise that selenium-chondroitin sulfate NPs could be a multifunctional agent for AD treatment, inhibiting both Aβ aggregation and attenuating the hyperphosphorylation of tau at Ser396 and Ser404 by regulating glycogen synthase kinase 3 β (Guo et al., 2016; He et al., 2018).