No significant association between genetic polymorphisms in TGFB1 (rs2241716 and rs4803455) and prognosis including progression-free survival (PFS) and overall survival (OS) in patients with non-metastatic disease was observed (Table 3, Supplementary Table 1 and Figures 1A, B). The gene discussed is TGFB1; the disease is metastatic neoplasm.