Tumors have been classified into 4 different TME types according to the presence or absence of tumor-infiltrating lymphocytes (TIL) and PD-L1 expression (Type I: TIL+, PD-L1+; Type II: TIL-, PD-L1-; Type III: TIL-, PD-L1+; and Type IV: TIL+, PD-L1-) (70). This evidence concerns the gene CD274 and neoplasm.