The potential translational significance of this link is enhanced by the observation that in non-diabetic human patients undergoing a cardiac procedure, increased circulating levels of FFA were associated with increased cardiac UCP2 and UCP3 expression and decreased expression of GLUT4, driving energy deficiency (Murray et al., 2004). The gene discussed is SLC2A4; the disease is hyperinsulinemic hypoglycemia, familial, 4.