SLC2A4 and familial dilated cardiomyopathy: Interestingly, cardiomyocyte specific knock out of GLUT4 in mice induces a similar phenotype to DCM, with cellular hypertrophy accompanied by an impairment in contractility and relaxation that is linked to altered calcium handling and at least partially explained by a significant reduction in ryanodine receptor and SERCA expression (Domenighetti et al., 2010).