It is well established that GLUT4 is the major contributor to glucose uptake in the beating heart and that GLUT4 levels are reduced in DCM, prompting Wende et al assert that ‘increasing or maintaining GLUT4 expression in the heart represents a reasonable approach for preserving myocardial glucose utilisation in the context of diabetes’ (Wende et al., 2020). The gene discussed is SLC2A4; the disease is familial dilated cardiomyopathy.