In breast cancer and glioblastoma cell lines, BAY 11-7085 (inhibitor of NK-κB activation) induced ferroptosis via nuclear factor-E2-related factor 2- (Nrf2-) solute carrier family 7 membrane 11 (SLC7A11)—heme oxygenase-1 (HO-1) pathway and causes compartmentalization of HO-1 into the nucleus and mitochondria, and followed mitochondrial dysfunctions, leading to lysosome targeting for mitophagy [146]. The gene discussed is HMOX1; the disease is breast carcinoma.