Histologic findings in DLE have some overlap with other CLE lesions, but overall, distinguishing features of active lesions include hyperkeratosis, vacuolar degeneration of the basal keratinocytes, significant follicular plugging, lymphocytic adnexal and deep perivascular infiltrates with subepidermal band, papillary dermal edema, initial atrophy, melanophages in the papillary dermis, and deposition of mucin among collagen fibers [7, 29, 40]. The gene discussed is MUC5AC; the disease is Hyperkeratosis.