In the present study, we have also identified the missense/non-sense heterozygous variants in the OTOG p.(Val1813Gly), SLC26A4 p.(Tyr556∗) CDH23 p.(Ala1631Val), GJB2 p.(Arg165Trp), and MYO15A p.(Arg1965His) genes which are predominant to cause deafness among Indian populations. The gene discussed is GJB2; the disease is deafness.