This mechanism underlies the regulation of the initial antigenic-specific immune response against COVID-19 and highlights a protective immunotype (composite of immune cell changes) consisting of hyperactive CD4+ and CD8+ T cells, reduced circulating TFH, and a robust plasmablast response that is positively correlated with disease severity while another immunotype consisting of minimal T and B cell activation (14). The gene discussed is CD4; the disease is COVID-19.