All these allograft models supported MYC-driven B-cell lymphomagenesis through increased protection against apoptosis, but only MYD88L252P or CARD11L244P Eμ-Myc tumors resembled to human ABC-DLBCL, including expression of PD-L1 which was responsible for an exhausted T-cell phenotype (12). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.