One is related to Chronic Lymphocytic Leukemia (CLL) with TCL1 (originally described in the former CD4 T-CLL, now called T-cell prolymphocytic leukemia) as a driver oncogene (33) and three others to marginal zone lymphomas, involving Traf3 deletion (34), BCL10 deregulation (35) and CD40 signaling (11). The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.