Here, using the CD4 T cell clone E2 isolated from the PBMCs of a new onset T1D patient (6), we describe the further characterization of the CD4 T cell response to HIP11, advancing our understanding of HIPs as autoantigens in T1D and providing a foundation for future efforts to investigate responses to HIPs during the development of T1D. This evidence concerns the gene CD4 and type 1 diabetes mellitus.