a) Elevation in IFN-γ secreted by activated thymic innate CD8+CD44hi single-positive (SP) thymocytes.b) Large amounts of cytokines secreted by CD122+CD44hiEomes+ innate T cells upon infected thymic DCs stimulation.c) Anti-IFN-γ therapy aids to attenuate thymic atrophy. The gene discussed is IL2RB; the disease is thymus atrophy.