Elevation of IL-10 was observed in PRRSV and Streptococcus suis, while elevation of IFN-γ was observed in PRRSV, IAV, Salmonella Typhimurium and Trypanosoma cruzi. IL-10 elevation is associated with thymic atrophy, while neem leaf glycoprotein (NLGP) can reverse tumor- and age-associated thymic atrophy through downregulating IL-10 (178). This evidence concerns the gene IL10 and thymus atrophy.