Although not all PBMCs from anti-EBP-1 IgG-positive patients had detectable IFN-γ production in response to rhEBP-1 stimulation, these data still suggest that EBP-1-specific T-cell IFN-γ response exists in the peripheral blood of CHB patients and might positively correlates with the severity of liver disease. This evidence concerns the gene IFNG and liver disorder.