REN and systemic lupus erythematosus: The top 20 prominent pathways, involved in systemic lupus erythematosus, necroptosis, vascular smooth muscle contraction, renin secretion, viral carcinogenesis, NOD-like receptor signaling, Gonadotropin-releasing hormone (GnRH) signaling, and inflammatory mediator regulation of transient receptor potential (TRP) channels were selected (Figures 1B–D).