In addition, IL-6 can perform completely different function depending on cell type and context; bone-morphogenetic protein 8b (BMP8b) takes part in the neurovascular remolding (46); NRG4 has a negative relation with acute coronary syndrome (ACS) (47); C-X-C motif chemokine ligand-14 (CXCL14) and growth differentiation factor 15 (GDF15) participate in anti-inflammation process (48, 49). Here, BMP8B is linked to acute coronary syndrome.