In some instances when both variants were studied, there was a lack of association with the MTHFR 677 T variant, but the MTHFR 1298 C variant (or CC homozygote) was associated with metabolic syndrome prevalence (48) or the development of worse metabolic outcomes following 3 months of atypical antipsychotic treatment (18). The gene discussed is MTHFR; the disease is metabolic syndrome.