NPPA and Hypertension: A recent study also showed that the accumulation and release of ANP from myocyte granules depends on the pathogenesis of hypertension, and described a higher number of ANP secretory granules in a salt loading model compared to two-kidney 1-clip hypertension, providing a possible explanation for the lack of increase in plasma ANP in our RV model (Bugrova and Galkina, 2020).