Among missense mutations, one AA change (G194A) alteration in the MIP domain was detected in 1 case of cancer, and one S196Lfs*17 alteration in the MIP domain was detected in 1 case of cancer (Figure 2B), which was able to induce amino mutations of the AQP4 gene at the 194 site of AQP4 protein, resulting in subsequent AQP4 protein truncation. Here, MIP is linked to cancer.