Although well known that 2K1C rats have an enhanced sodium intake induced by WD (Roncari et al., 2018), that sodium intake can worsen the glomerular injury caused by 2K1C hypertension (Olson et al., 1986; Liu et al., 1993; Menendez-Castro et al., 2020), and that these animals also have an increased RAAS (Leenen et al., 1975; Lincevicius et al., 2015; Textor, 2017; Roncari et al., 2018), it is not known if the high WD-induced sodium intake in these animals is due to the activation of ANG II and/or aldosterone receptors in the brain. This evidence concerns the gene NR3C2 and Wilson disease.