Combined with the activation of macrophages, such impact on ACE2 could be involved in the development of COVID-19-related fibrosis (He et al., 2006; Meng et al., 2014; Patel et al., 2016; Rodrigues Prestes et al., 2017; Smigiel and Parks, 2018; Banu et al., 2020; Pagliaro, 2020). Here, ACE2 is linked to COVID-19.