Tau pathology was reported to be involved in several central nervous system (CNS) diseases, including AD, vascular dementia, traumatic brain injury, and multiple sclerosis (Hu et al., 2018; Chidambaram et al., 2020; Mirzaii-Dizgah et al., 2020; Shi et al., 2020). The gene discussed is MAPT; the disease is multiple sclerosis.