Introduction of the R192Q missense mutation, previously found in patients with hemiplegic migraine (Ophoff et al., 1996), in the orthologous mouse Cacna1a gene resulted in a transgenic FHM1 R192Q knock-in (“R192Q KI”) mouse model (van den Maagdenberg et al., 2004) that expresses key features of migraine pathophysiology and was instrumental in unraveling mechanisms of migraine pathophysiology (Ferrari et al., 2015; Pietrobon and Brennan, 2019). Here, CACNA1A is linked to migraine disorder.