Hou J. et al. (2019) demonstrated high TROP2 expression on GBM cells from surgically removed patient tumors compared to low levels on normal brain cells. Its expression level was found to inversely correlate with survival in GMB patients (Hou J. et al., 2019). TROP2 is thought to modulate cell proliferation and promote metastasis via activation of JAK/STAT3 pathway (Hou J. et al., 2019). Furthermore, in GBM TROP2 is associated with promotion of blood vessel formation through VEGF upregulation (Hou J. et al., 2019). This evidence concerns the gene STAT3 and glioblastoma.