Therefore, this modulation of the TME is expected to enhance CAR T cell activity (Ajina and Maher, 2017), Huang et al., generated an IL-7-loaded oncolytic adenovirus (oAD-IL7) and used it in combination with B7-H3-specific CAR T cells for the treatment of mice orthotopically grafted with GBM cells (Huang et al., 2021). Here, CD276 is linked to glioblastoma.